Museum of Art to screen film about Rock and Roll Singer Wanda Jackson, The "Sweet Lady with the Nasty Voice."
OKLAHOMA CITY – The Oklahoma City Museum of Art will screen the award winning documentary film about Oklahoma's own "Queen of Rockabilly," Wanda Jackson. The film entitled "Wanda Jackson: The Sweet Lady with the Nasty Voice" will screen Thursday, September 6 through Sunday, September 9 at the Museum of Art's Noble Theater. Ms. Jackson will appear in person at the final screening on Sunday, September 9 at 2pm to meet fans and sign CDs.
After appearing as a country singer on an Oklahoma City radio show, Wanda was invited to record with country legend Hank Thompson on the Decca label in 1954. Then she began dating a young Elvis Presley who convinced her to begin performing rock and roll songs. Before long she was touring with Elvis, Jerry Lee Lewis and Buddy Holly. Wanda signed with Capitol Records in 1956 where she had her first chart success with the song "Let's Have a Party." Wanda Jackson is often called the first female rock and roll singer.
Wanda Jackson has been inducted into the Oklahoma Country Music Hall of Fame, the Rockabilly Hall of Fame, the International Hall of Fame, the International Gospel Music Hall of Fame, the Oklahoma Music Hall of Fame, and the German Country Music Hall of Fame, but remains conspicuously absent from the Rock and Roll and Country Music Halls of Fame.
During her 2005 U.S. and European tour a camera crew filmed her performances from her latest album release "I Remember Elvis" in venues ranging from New York City to Sweden. This footage combined with archival film footage, photographs and interviews with Wanda, her husband and manager of forty-five years Wendell Goodman, as well as artists such as Bruce Springsteen and Elvis Costello, tells the story of the "Sweet Lady with the Nasty Voice."
"Wanda Jackson: The Sweet Lady with the Nasty Voice" world premiered at the 2007 deadCENTER Film Festival in Oklahoma City where it won the Founder's Award. The film is produced and directed by Joanne Fish and Victor Kralyevich.
Oklahoma City Museum of Art
Thursday, July 19, 2007
Tuesday, July 17, 2007
Would you like fries with that?
16 July 2007
Would you like fries with that?
Exploiting interactions between food and drugs could dramatically lower the rapidly rising costs of several anticancer drugs, and perhaps many other medications, two cancer-pharmacology specialists suggest.
University of Chicago oncologists Mark Ratain, MD, and Ezra Cohen, MD, call attention in today’s issue of the Journal of Clinical Oncology to the flip side of recent studies showing how certain foods can alter absorption or delay breakdown of precisely targeted anti-cancer drugs.
Instead of seeing such studies as highlighting a dosing problem, Ratain and Cohen argue that results like this one should point researchers toward a partial solution, a novel way to decrease medication costs while increasing benefits from these effective but expensive drugs.
The commentary was inspired by a study presented in June at the American Society for Clinical Oncology. Researchers from Dartmouth showed that taking the breast cancer drug lapatinib (TYKERB) with food—instead of on an empty stomach as suggested on the label—resulted in more of the drug being absorbed and available to treat the cancer.
Patients currently take five 250 mg lapatinib tablets on an empty stomach. The study found that taking the drug with a meal increased the bioavailability of the drug by 167 percent. Taking the drug with a high-fat meal boosted levels by 325 percent.
"Simply by changing the timing, taking this medication with a meal instead of on an empty stomach, we could potentially use 40 percent (or even less) of the drug," said Ratain. "Since lapatinib costs about $2,900 a month, this could save each patient $1,740 or more a month."
Topping off that meal with grapefruit juice, "which may also increase plasma concentrations" according to the package insert, could increase the savings to 80 percent, the authors suggest, "minus the cost of the food and juice."
"We expect the one 250 mg lapatinib pill accompanied by food and washed down with a glass of grapefruit juice may yield plasma concentrations comparable to five 250 mg pills on an empty stomach," Ratain said.
Such a "value meal," the authors add, may have other benefits. The major toxicity associated with lapatinib is diarrhoea, probably caused by unabsorbed drug. So taking a lower dose with food should "reduce the amount of unabsorbed drug, and therefore theoretically also reduce the frequency and severity of diarrhoea."
Patients should NEVER launch such experiments on their own, the authors caution. Such food-drug combinations should be studied to assess the effects, note person-to-person variations, and enable physicians to predict how individual patients will take up and metabolize specific drugs in the presence of certain foods.
"The one thing that should not be anticipated is an efficacy study by lapatinib's sponsor," the authors write. Such studies could be mounted by other entities, however, such as the Federal government, other payers or advocacy groups.
Ratain and Cohen are currently conducting such a study, a phase I trial of the combination of oral sirolimus (rapamycin) taken with grapefruit juice, which contains substances that delay the breakdown of many drugs.
Dozens, perhaps hundreds, of drugs ought to be studied in this way, the authors said. "If we understood the relationship between, say, grapefruit juice and common drugs, such as the statins, which taken daily by millions of people to prevent heart disease, we could save a fortune in drug costs," Cohen said. "And patients would get a little vitamin C to boot."
Brought to you by: http://www.biochemist.com/news/page.htm?item=23551
Would you like fries with that?
Exploiting interactions between food and drugs could dramatically lower the rapidly rising costs of several anticancer drugs, and perhaps many other medications, two cancer-pharmacology specialists suggest.
University of Chicago oncologists Mark Ratain, MD, and Ezra Cohen, MD, call attention in today’s issue of the Journal of Clinical Oncology to the flip side of recent studies showing how certain foods can alter absorption or delay breakdown of precisely targeted anti-cancer drugs.
Instead of seeing such studies as highlighting a dosing problem, Ratain and Cohen argue that results like this one should point researchers toward a partial solution, a novel way to decrease medication costs while increasing benefits from these effective but expensive drugs.
The commentary was inspired by a study presented in June at the American Society for Clinical Oncology. Researchers from Dartmouth showed that taking the breast cancer drug lapatinib (TYKERB) with food—instead of on an empty stomach as suggested on the label—resulted in more of the drug being absorbed and available to treat the cancer.
Patients currently take five 250 mg lapatinib tablets on an empty stomach. The study found that taking the drug with a meal increased the bioavailability of the drug by 167 percent. Taking the drug with a high-fat meal boosted levels by 325 percent.
"Simply by changing the timing, taking this medication with a meal instead of on an empty stomach, we could potentially use 40 percent (or even less) of the drug," said Ratain. "Since lapatinib costs about $2,900 a month, this could save each patient $1,740 or more a month."
Topping off that meal with grapefruit juice, "which may also increase plasma concentrations" according to the package insert, could increase the savings to 80 percent, the authors suggest, "minus the cost of the food and juice."
"We expect the one 250 mg lapatinib pill accompanied by food and washed down with a glass of grapefruit juice may yield plasma concentrations comparable to five 250 mg pills on an empty stomach," Ratain said.
Such a "value meal," the authors add, may have other benefits. The major toxicity associated with lapatinib is diarrhoea, probably caused by unabsorbed drug. So taking a lower dose with food should "reduce the amount of unabsorbed drug, and therefore theoretically also reduce the frequency and severity of diarrhoea."
Patients should NEVER launch such experiments on their own, the authors caution. Such food-drug combinations should be studied to assess the effects, note person-to-person variations, and enable physicians to predict how individual patients will take up and metabolize specific drugs in the presence of certain foods.
"The one thing that should not be anticipated is an efficacy study by lapatinib's sponsor," the authors write. Such studies could be mounted by other entities, however, such as the Federal government, other payers or advocacy groups.
Ratain and Cohen are currently conducting such a study, a phase I trial of the combination of oral sirolimus (rapamycin) taken with grapefruit juice, which contains substances that delay the breakdown of many drugs.
Dozens, perhaps hundreds, of drugs ought to be studied in this way, the authors said. "If we understood the relationship between, say, grapefruit juice and common drugs, such as the statins, which taken daily by millions of people to prevent heart disease, we could save a fortune in drug costs," Cohen said. "And patients would get a little vitamin C to boot."
Brought to you by: http://www.biochemist.com/news/page.htm?item=23551
Thursday, July 5, 2007
Laptop Joy
For anyone who doesn't own a laptop, let me tell you how mine has come in handy over the course of the last couple of months. It has paid for itself over and over again in so many ways.
I write. I write a lot. MY web sites require updates regularly, I blog and I send an insane number of emails. Not only that, but I write for the graduate classes I take. I just finished a research paper for Educational Psychology and the beauty is that I started it in Gulf Shores, AL. I researched it in AL and wrote the outline on my laptop, then emailed it to my instructor in Texas.
On the way home, I fired up the laptop and worked on some projects from the comfort of the front passenger seat of our SUV. You can't do that on a desktop. :)
The kids also watched DVD's while we drove to and from the beach. The screen is larger than most personal DVD players, too.
Last, but not least, we uploaded our digital pictures while we were still at the beach house and made CD's to send home with the other family members.
It's amazing to me how much this computer has come in handy - for just one trip.
I just had to share. If you're thinking about getting one and aren't sure they're worth it, believe me, they are.
Enjoy!
I write. I write a lot. MY web sites require updates regularly, I blog and I send an insane number of emails. Not only that, but I write for the graduate classes I take. I just finished a research paper for Educational Psychology and the beauty is that I started it in Gulf Shores, AL. I researched it in AL and wrote the outline on my laptop, then emailed it to my instructor in Texas.
On the way home, I fired up the laptop and worked on some projects from the comfort of the front passenger seat of our SUV. You can't do that on a desktop. :)
The kids also watched DVD's while we drove to and from the beach. The screen is larger than most personal DVD players, too.
Last, but not least, we uploaded our digital pictures while we were still at the beach house and made CD's to send home with the other family members.
It's amazing to me how much this computer has come in handy - for just one trip.
I just had to share. If you're thinking about getting one and aren't sure they're worth it, believe me, they are.
Enjoy!
Wednesday, July 4, 2007
Vacation in Gulf Shores, AL
Took a wonderful vacation to Gulf Shores, AL. If you ever get a chance to go, please do. It's an amazing place. We always rent through Fort Morgan Realty and they have never let us down. We stay closer to Ft. Morgan than Gulf Shores. The traffic is less and the beaches are quieter.
The weather was amazing, the kids were wonderful and we had such a great time. I even joined in to go deep sea fishing and had a blast. I couldn't believe how sore my arms were the next day, however.
The only bummer about the whole situation was that my father spent a large portion of the trip in a hospital in Foley with an infection that just didn't respond to treatment as it should have.
We had fun for him, which wasn't the same for him, but it was the best we could do. At least he will enjoy the fish we caught... red snapper and king mackerel.
The weather was amazing, the kids were wonderful and we had such a great time. I even joined in to go deep sea fishing and had a blast. I couldn't believe how sore my arms were the next day, however.
The only bummer about the whole situation was that my father spent a large portion of the trip in a hospital in Foley with an infection that just didn't respond to treatment as it should have.
We had fun for him, which wasn't the same for him, but it was the best we could do. At least he will enjoy the fish we caught... red snapper and king mackerel.
Sunday, June 10, 2007
Bethany Update
Bethany is doing well. She came home on Wednesday evening after 3 days of testing and 30 hours of sleep deprivation. She had to endure many others tests as well, but she is recovering nicely.
She is now off her epilepsy medication and we're really praying that she never has to go back on it again. Her EEG is still abnormal, but isn't indicating seizures at this time. There is more going on with the left side of her brain than the right, but again, no seizures are evident.
The doctor was unable to determine the cause of the "episodes" she'd been having as nothing happened while we were in the hospital. Isn't that how it always works? We will keep a close eye on Bethany until we're convinced nothing is going to happen (which for me may take months).
At this time, we are cautiously optimistic about her future - without epilepsy. We have been this route before with her going off her meds and doing well for years, but I'm trying to be hopeful that it's really going to "stick" this time. :)
Thank you for your prayers. God is truly taking care of us.
She is now off her epilepsy medication and we're really praying that she never has to go back on it again. Her EEG is still abnormal, but isn't indicating seizures at this time. There is more going on with the left side of her brain than the right, but again, no seizures are evident.
The doctor was unable to determine the cause of the "episodes" she'd been having as nothing happened while we were in the hospital. Isn't that how it always works? We will keep a close eye on Bethany until we're convinced nothing is going to happen (which for me may take months).
At this time, we are cautiously optimistic about her future - without epilepsy. We have been this route before with her going off her meds and doing well for years, but I'm trying to be hopeful that it's really going to "stick" this time. :)
Thank you for your prayers. God is truly taking care of us.
Thursday, June 7, 2007
My Student Experiences
This is a portion of a discussion for a class I am taking at Texas A&M University at Commerce. The course is Educational Psychology.
Tell about a favorite teacher and how his/her teaching methods made a difference in your life:
I wish I had a teacher that really stuck out in my mind, but unfortunately, I do not. None of my teachers in elementary school, junior high school or high school made much of an impact on me. In fact, I can't remember hardly any of their names.
I remember my fourth grade teacher used alcohol on her hands to clean them from the germs in our class, but she told me to never do it myself.
My sixth grade teacher had the girls in her class file her nails and brush her hair for her.
I had one teacher in junior high mark one of my answers on a test wrong even though I could prove that it was right - but it wasn't the answer she was looking for.
The only thing I really remember about high school was a creative writing course I took and the teacher said my writing was very good. I don't remember a single teacher's name from high school.
I went to at least 9 schools from K - 12. I wasn't a bad kid and we only moved one time. Desegregation, building a new school, going to a private school for awhile, and so on meant I didn't end up with a lot of continuity.
In spite of all of that, I was a straight-A student.
In college, I did have three teachers stand out. One because she helped me to see that a written work I created could be critically evaluated without it becoming a criticism of me personally. Another teacher stood out because he had principles and was very demanding of his students. The third stood out because he truly believed my writing was good and gave me opportunities to share it within the university setting and outside of it as well.
I know I added more to this discussion than necessary, but I also think it's important to note all the teachers who failed to make an impression on me as well.
~Carla
Tell about a favorite teacher and how his/her teaching methods made a difference in your life:
I wish I had a teacher that really stuck out in my mind, but unfortunately, I do not. None of my teachers in elementary school, junior high school or high school made much of an impact on me. In fact, I can't remember hardly any of their names.
I remember my fourth grade teacher used alcohol on her hands to clean them from the germs in our class, but she told me to never do it myself.
My sixth grade teacher had the girls in her class file her nails and brush her hair for her.
I had one teacher in junior high mark one of my answers on a test wrong even though I could prove that it was right - but it wasn't the answer she was looking for.
The only thing I really remember about high school was a creative writing course I took and the teacher said my writing was very good. I don't remember a single teacher's name from high school.
I went to at least 9 schools from K - 12. I wasn't a bad kid and we only moved one time. Desegregation, building a new school, going to a private school for awhile, and so on meant I didn't end up with a lot of continuity.
In spite of all of that, I was a straight-A student.
In college, I did have three teachers stand out. One because she helped me to see that a written work I created could be critically evaluated without it becoming a criticism of me personally. Another teacher stood out because he had principles and was very demanding of his students. The third stood out because he truly believed my writing was good and gave me opportunities to share it within the university setting and outside of it as well.
I know I added more to this discussion than necessary, but I also think it's important to note all the teachers who failed to make an impression on me as well.
~Carla
Friday, June 1, 2007
Student Teaching
Earlier this week, I was told where I would be placed for student teaching and I wrapped my mind around the fact that it wasn't my first choice. It was my second choice, but it's the farthest possible school from my home. The good part is that it's likely the best school in the district located in one of the most amazing parts of town. The teacher that I would be working with is a "teacher trainer" for the district. They are on the cutting edge of all new education concepts.
My first choice, however, is the school where my youngest daughter attends and is walking distance from our house. It is demographically diverse and has a principal that I adore. In fact, this principal caught me yesterday and said that apparently my placement drama isn't over as he received an email asking if I could be placed in his school afterall - even though I'd already been told it was not an option. Ugghhhh. I keep praying about it, but I'm not sure what would be best for me. Do I step in? Which school is best? It's so frustrating.
I am not fond of these kinds of roller coasters. This has been going on for 3 weeks. Back and forth.... I mention this as it was actually a goal this week to get it all nailed down finally.
My first choice, however, is the school where my youngest daughter attends and is walking distance from our house. It is demographically diverse and has a principal that I adore. In fact, this principal caught me yesterday and said that apparently my placement drama isn't over as he received an email asking if I could be placed in his school afterall - even though I'd already been told it was not an option. Ugghhhh. I keep praying about it, but I'm not sure what would be best for me. Do I step in? Which school is best? It's so frustrating.
I am not fond of these kinds of roller coasters. This has been going on for 3 weeks. Back and forth.... I mention this as it was actually a goal this week to get it all nailed down finally.
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